/*! This file is auto-generated */ .wp-block-button__link{color:#fff;background-color:#32373c;border-radius:9999px;box-shadow:none;text-decoration:none;padding:calc(.667em + 2px) calc(1.333em + 2px);font-size:1.125em}.wp-block-file__button{background:#32373c;color:#fff;text-decoration:none} Q53 E Olestra is a fat substitute appr... [FREE SOLUTION] | 魅影直播

魅影直播

Olestra is a fat substitute approved by the FDA for use in snack foods. Because there have been anecdotal reports of gastrointestinal problems associated with olestra consumption, a randomized, double-blind, placebo-controlled experiment was carried out to compare olestra potato chips to regular potato chips with respect to GI symptoms ("Gastrointestinal Symptoms Following Consumption of Olestra or Regular Triglyceride Potato Chips," J. of the Amer. Med. Assoc., 1998: 150-152). Among 529 individuals in the TG control group, 17.6 % experienced an adverse GI event, whereas among the 563 individuals in the olestra treatment group, 15.8 % experienced such an event.

a. Carry out a test of hypotheses at the 5 % significance level to decide whether the incidence rate of GI problems for those who consume olestra chips according to the experimental regimen differs from the incidence rate for the TG control treatment.

b. If the true percentages for the two treatments were 15 % and 20 %, respectively, what sample sizes

\((m = n\)) would be necessary to detect such a difference with probability 90?

Short Answer

Expert verified

(a) There is not sufficient evidence to support the claim that the incidence rate of Gl problems for those who consume olestra chips according to the experimental regimen differs from the incidence rate for the TG control group.

(b) \(n = 1211\)\(\)

Step by step solution

01

To determine the value of the test statistic

Given:

a)

\(\begin{array}{l}{{\hat p}_1} = 17.6\% = 0.176\\{n_1} = 529\\{{\hat p}_2} = 15.8\% = 0.158\\{n_2} = 563\\\alpha = 5\% = 0.05\end{array}\)

(a) Claim: \({p_1} \ne {p_2}\)

The claim is either the null hypothesis or the alternative hypothesis. The null hypothesis states an equality. Since the null hypothesis is not the claim, the alternative hypothesis is the claim.

\(\begin{array}{l}{H_0}:{p_1} = {p_2}\\{H_a}:{p_1} \ne {p_2}\end{array}\)

The sample proportion is the number of successes divided by the sample size:

\(\begin{array}{l}{x_1} = {{\hat p}_1}{n_1} = 0.176(529) \approx 93\\{x_2} = {{\hat p}_2}{n_2} = 0.158(563) \approx 89\end{array}\)

\({\hat p_p} = \frac{{{x_1} + {x_2}}}{{{n_1} + {n_2}}} = \frac{{93 + 89}}{{529 + 563}} = \frac{1}{6} \approx 0.1667\)

The critical values are the values corresponding to a probability of \(0.025/0.975\) in table A.3:

\(z = \pm 1.96\)

The rejection region then contains all values below -1.96 and all values above 1.96.

Determine the value of the test statistic:

\(z = \frac{{{{\hat p}_1} - {{\hat p}_2}}}{{\sqrt {{{\hat p}_p}\left( {1 - {{\hat p}_p}} \right)} \sqrt {\frac{1}{{{n_1}}} + \frac{1}{{{n_2}}}} }} = \frac{{0.176 - 0.158}}{{\sqrt {0.1667(1 - 0.1667)} \sqrt {\frac{1}{{529}} + \frac{1}{{563}}} }} \approx 0.80\)

If the value of the test statistic is within the rejection region, then the null hypothesis is rejected:

\( - 1.96 < 0.80 < 1.96 \Rightarrow {\rm{ Fail to reject }}{H_0}\)

There is not sufficient evidence to support the claim that the incidence rate of Gl problems for those who consume olestra chips according to the experimental regimen differs from the incidence rate for the TG control group.

02

To find the n value for the given sample sizes

(b) Given: Sample sizes are equal.

\(\begin{array}{l}{p_1} = 15\% = 0.15\\{p_2} = 20\% = 0.20\\P\left( {{\rm{ Reject }}{H_0}\mid {H_0}{\rm{ false }}} \right) = 0.90\end{array}\)

\({q_1}\)is the complement of \({p_1}\)and \({q_2}\)is the complement of \({p_2}\).

\(\begin{array}{l}{q_1} = 1 - {p_1} = 1 - 0.15 = 0.85\\{q_2} = 1 - {p_2} = 1 - 0.20 = 0.80\end{array}\)

\(\beta \)is the probability of not rejecting the null hypothesis when the null hypothesis \({H_0}\)is false (use the complement rule):

\(\beta = 1 - P\left( {{\rm{ Reject }}{H_0}\mid {H_0}{\rm{ false }}} \right) = 1 - 0.90 = 0.10\)

The critical value of the significance level \(\alpha \) is the value corresponding to a probability of \(\alpha /2 = 0.025\) in table A.3:

\({z_{\alpha /2}} = 1.96\)

The critical value of the probability of a type II error \(\beta \) is the value corresponding to a probability of 0.10 in table A.3:

\({z_\beta } = 1.28\)

\(d\)is the difference in population means:

\(d = {p_1} - {p_2} = 0.15 - 0.20 = - 0.05\)

Formula sample size:

Fill in the known values and evaluate (round up!):\(n = {\frac{{1.96\sqrt {(0.15 + 0.20)(0.85 + 0.80)/2} + 1.28\sqrt {0.15(0.85) + 0.20(0.80)} }}{{{{( - 0.05)}^2}}}^2} \approx 1211\)\(\)\(\)

03

Final proof

(a) There is not sufficient evidence to support the claim that the incidence rate of Gl problems for those who consume olestra chips according to the experimental regimen differs from the incidence rate for the TG control group.

(b) \(n = 1211\)\(\)

Unlock Step-by-Step Solutions & Ace Your Exams!

  • Full Textbook Solutions

    Get detailed explanations and key concepts

  • Unlimited Al creation

    Al flashcards, explanations, exams and more...

  • Ads-free access

    To over 500 millions flashcards

  • Money-back guarantee

    We refund you if you fail your exam.

Over 30 million students worldwide already upgrade their learning with 魅影直播!

One App. One Place for Learning.

All the tools & learning materials you need for study success - in one app.

Get started for free

Most popular questions from this chapter

Antipsychotic drugs are widely prescribed for conditions such as schizophrenia and bipolar disease. The article "Cardiometabolic Risk of SecondGeneration Antipsychotic Medications During First-Time Use in Children and Adolescents"\((J\). of the Amer. Med. Assoc., 2009) reported on body composition and metabolic changes for individuals who had taken various antipsychotic drugs for short periods of time.

a. The sample of 41 individuals who had taken aripiprazole had a mean change in total cholesterol (mg/dL) of\(3.75\), and the estimated standard error\({s_D}/\sqrt n \)was\(3.878\). Calculate a confidence interval with confidence level approximately\(95\% \)for the true average increase in total cholesterol under these circumstances (the cited article included this CI).

b. The article also reported that for a sample of 36 individuals who had taken quetiapine, the sample mean cholesterol level change and estimated standard error were\(9.05\)and\(4.256\), respectively. Making any necessary assumptions about the distribution of change in cholesterol level, does the choice of significance level impact your conclusion as to whether true average cholesterol level increases? Explain. (Note: The article included a\(P\)-value.)

c. For the sample of 45 individuals who had taken olanzapine, the article reported\(99\% CI\)as a\(95\% \)CI for true average weight gain\((kg)\). What is a $\(99\% CI\)?

Consider the accompanying data on breaking load (\(kg/25\;mm\)width) for various fabrics in both an unabraded condition and an abraded condition (\(^6\)The Effect of Wet Abrasive Wear on the Tensile Properties of Cotton and Polyester-Cotton Fabrics," J. Testing and Evaluation, \(\;1993:84 - 93\)). Use the paired\(t\)test, as did the authors of the cited article, to test\({H_0}:{\mu _D} = 0\)versus\({H_a}:{\mu _D} > 0\)at significance level . \(01\)

The article "Fatigue Testing of Condoms" cited in Exercise 7.32 reported that for a sample of 20 natural latex condoms of a certain type, the sample mean and sample standard deviation of the number of cycles to break were 4358 and 2218 , respectively, whereas a sample of 20 polyisoprene condoms gave a sample mean and sample standard deviation of 5805 and 3990 , respectively. Is there strong evidence for concluding that true average number of cycles to break for the polyisoprene condom exceeds that for the natural latex condom by more than 1000 cycles? Carry out a test using a significance level of 01 . (Note: The cited paper reported P-values of t tests for comparing means of the various types considered.)

The article "Enhancement of Compressive Properties of Failed Concrete Cylinders with Polymer Impregnation" (J. of Testing and Evaluation, 1977: 333-337) reports the following data on impregnated compressive modulus (\(psi\)\( \times 1{0^6}\)) when two different polymers were used to repair cracks in failed concrete.

\(\begin{array}{*{20}{l}}{ Epoxy }&{1.75}&{2.12}&{2.05}&{1.97}\\{ MMA prepolymer }&{1.77}&{1.59}&{1.70}&{1.69}\end{array}\)

Obtain a \(90\% \) CI for the ratio of variances by first using the method suggested in the text to obtain a general confidence interval formula.

Which way of dispensing champagne, the traditional vertical method or a tilted beer-like pour,preserves more of the tiny gas bubbles that improve flavor and aroma? The following data was reported in the article 鈥淥n the Losses of Dissolved \(C{O_2}\) during Champagne Serving鈥 (J. Agr. Food Chem., 2010: 8768鈥8775)

\(\begin{array}{*{20}{c}}{ Temp \left( {^^\circ C} \right)}&{ Type of Pour }&n&{ Mean (g/L)}&{ SD }\\{18}&{ Traditional }&4&{4.0}&{.5}\\{18}&{ Slanted }&4&{3.7}&{.3}\\{12}&{ Traditional }&4&{3.3}&{.2}\\{12}&{ Slanted }&4&{2.0}&{.3}\\{}&{}&{}&{}&{}\end{array}\)

Assume that the sampled distributions are normal.

a. Carry out a test at significance level \(.01\) to decide whether true average\(C{O_2}\)loss at \(1{8^o}C\) for the traditional pour differs from that for the slanted pour.

b. Repeat the test of hypotheses suggested in (a) for the \(1{2^o}\) temperature. Is the conclusion different from that for the \(1{8^o}\) temperature? Note: The \(1{2^o}\) result was reported in the popular media

See all solutions

Recommended explanations on Math Textbooks

View all explanations

What do you think about this solution?

We value your feedback to improve our textbook solutions.

Study anywhere. Anytime. Across all devices.